Lumpy skin disease (LSD) is a cutaneous disease of livestock caused by a DNA-containing virus belonging to Poxviridae family called Lumpy Skin Disease Virus (LSDV). Another name of the virus is Neethling. The disease is characterized mainly by fever, and lesions appearing on the skin. The incubation period is 6-9 days. Mortality of the disease is about 10%, however, secondary infection of lesions can increase the mortality rate. LSD was first recorded in Zambia, South Africa, then spread to Sudan, Nigeria and European countries.