Drug overdose claimed the lives of more than 63,000 Americans in 2016. The majority of these deaths, over 42,000, involved opioids such as heroin, prescription painkillers, and, increasingly, illicitly manufactured fentanyl. Indiana is not immune to this national crisis. In 2003, for example, only three Indiana residents died from heroin-related overdose. In 2016, the number was 296.