The International Society for Disease Surveillance held its eleventh annual conference in San Diego on December 4th and 5th, 2012, under the theme Expanding Collaborations to Chart a New Course in Public Health Surveillance.  During these two days, practitioners and researchers across many disciplines gathered to share best practices, lessons learned and cutting edge approaches to timely disease surveillance.  A record number of abstracts were received, reviewed and presented – the schedule included 99 orals, 4 panels, 94 posters, 5 roundtables and 12 system demonstrations.  Presenters represented 24 different countries from Africa, North and South America, Europe, and Asia .  Topics covered included, but were not limited to, statistical methods for outbreak detection, border health, data quality, evaluation of novel data streams, influenza surveillance, best practices and policies for information sharing, social network analysis, data mining techniques, surveillance during weather events and mass gatherings, syndrome development, and novel uses of syndromic surveillance data.  There were also discussions on the impact of regulations and standards development on disease surveillance, including Meaningful Use and the International Health Regulations.